Anti-Thyroid Peroxidase Antibody (TPOAb)
METHODOLOGY
Immunoassay
PERFORMED
Thursday
REPORTED
1-5 days
COLLECT
One 6 mL RT (Min: 4 mL RT)
TRANSPORT
2.0 mL refrigerated serum (Min: 0.5 mL)
STABILITY
Stored at 2 - 8°C until used; Stable if frozen at - 20°C
UNACCEPTABLE SPECIMENS
Whole blood/Plasma; Slightly and moderately lipemic, hemolyzed or icteric samples are acceptable. Samples that are grossly lipemic, icteric or hemolyzed are to be brought to the attention of the Supervisory Staff for approval.
REFERENCE RANGE
<5.0 IU/mL
CPT CODE
86376
INFORMATION
Thyroid peroxidase autoantibodies (TPOAb) are of pathological importance because they are present in the majority of Hashimoto’s thyroiditis patients and correlate with the active phase of the disease. Unlike thyroglobulin autoantibodies (TgAb), they may damage thyroid cells by complement fixation. The detection of thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb), and the measurement of thyroid stimulating hormone, have been used in determining the diagnosis and management of autoimmune thyroid disorders.