Anti-Thyroglobulin Antibody (TgAb)
METHODOLOGY
Radioimmunoassay
PERFORMED
Monday - Friday
REPORTED
Next Working Day
COLLECT
One 6mL RT (Min: 4 mL RT)
TRANSPORT
1.0 mL refrigerated serum (Min: 0.5 mL)
STABILITY
Stored at 2 - 8°C until used; Stable if frozen at - 20°C
UNACCEPTABLE SPECIMENS
Whole blood/Plasma; Slightly and moderately lipemic, hemolyzed or icteric samples are acceptable. Samples that are grossly lipemic, icteric or hemolyzed are to be brought to the attention of the Supervisory Staff for approval.
REFERENCE RANGE
<0.4 U/mL
CPT CODE
​
86800
INFORMATION
This highly sensitive, direct radioimmunoassay system is based on the use of a highly purified, stable preparation of 125I labeled Thyroglobulin. The assay is standardized against the MRC Thyroglobulin Auto-antibody First International Reference Preparation (Coded 65/93).
Measurement of thyroglobulin auto-antibodies can be of considerable value in the diagnosis of thyroid diseases, such as autoimmune thyroiditis, Graves' disease, endemic goiter and subacute thyroiditis. These measurements when used as part of a thyroid autoimmune diagnostic profile, which would include Anti Thyroid Peroxidase Antibody and Thyrotropin Receptor antibody, can be very useful in the differential diagnosis and management of thyroid disease. TgAb is always to be run in conjunction with Thyroglobulin (Tg) sera in order to conform to NACB guidelines (Thyroid 13:1, 2003).